Blar i forfatter "Bouř, Petr"

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    • Anti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell lines 

      Isaksson, Johan; Rylandsholm, Fredrik G.; Bouř, Petr; Svendsen, John Sigurd Mjøen; Brichtová, Eva; Choi, Sng Un; Lee, Sang‑Ho; Jung, Young-Sik; No, Zae Sung; Aasen, Arne Jørgen; Dekebo, Aman; Dinku, Worku (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-17)
      Myrrh, a resin derived from the damaged bark of Commiphora genus, has traditionally been used for treatment of various human diseases, such as amenorrhea, ache, tumors, fever, and stomach pains. In spite of this widespread use of the myrrh in Ethiopia, the pharmacological activity and chemical composition have not been studied in detail. A new tricyclic triterpene acid (3S,4S,14S,7E,17E,21Z)-3, ...

    • Glucagon-like peptide 1 aggregates into low-molecular-weight oligomers off-pathway to fibrillation 

      Přáda Brichtová, Eva; Monika, Krupová; Bouř, Petr; Lindo, Viv; Gomes dos Santos, Ana; Jackson, Sophie E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-20)
      The physical stability of peptide-based drugs is of great interest to the pharmaceutical industry. Glucagon-like peptide 1 (GLP-1) is a 31-amino acid peptide hormone, the analogs of which are frequently used in the treatment of type 2 diabetes. We investigated the physical stability of GLP-1 and its C-terminal amide derivative, GLP-1-Am, both of which aggregate into amyloid fibrils. While off-pathway ...